Serum chemokine and cytokine levels in wild-type and Cav-1 null mice during T. cruzi infection.
A) IFN-γ levels. Analysis of serum IFN-γ levels in wild-type (WT) and Cav-1 null (KO) animals before infection (day 0) and at 14 days post-infection reveals a normal increase in this cytokine following infection in WT animals, but a severely blunted response in Cav-1 null mice.
B) TNF-α levels. Serum levels of TNF-α are also significantly reduced in Cav-1 null mice at 14 days post-infection.
Results represent the mean ± SEM; *p<0.05, n ≥ 5 animals per group.