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The high-risk tumor subvolume (nodule) (e.g. a dominant intraprostatic lesion (DIL) for prostate cancer) set-up for 100% specificity and sensitivity of a functional imaging (a). The resulting imaged-and-occult high-risk subvolumes set-ups due to specificity loss are on the diagram (b) – (d). The nodules as sensitivity loss (e)-(h).
