Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
(a) Response surface of a combination of full agonist B with partial agonist A. At low concentrations, A adds to the effect produced by B. At large concentrations, A competes with B for receptors, lowering the joint effect.
(b) Isoboles of the response surface in (a). The isoboles are always linear, but switch from negative to positive slope as the maximal effect of partial agonist A (here, αA=0.25) is exceeded.
