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. Author manuscript; available in PMC: 2009 Sep 3.
Published in final edited form as: Mol Cell Endocrinol. 2008 May 2;290(1-2):51–59. doi: 10.1016/j.mce.2008.04.013

Figure 1. Tom20/22 and Tom70 receptors potential targeting of ERβ.

Figure 1

A simplistic diagram of potential ERβ mitochondrial import through Tom receptor mediated activity. The Tom complex can recognize protein such as ERβ through two major receptor transport pathways, Tom20/Tom22 or Tom70. Tom20 with Tom22 can recognize a LXXLL presequences available in ligand bound ERβ (N-terminal or internal), then bind and transport ERβ across the outer membrane to the inner membrane or TIM complex. Alternatively, unliganded ERβ can be recognized by Tom70 through its chaparone complex, Hsp90/70. Hsp90 and Hsp70 can target proteins without a presequence by docking to tetraticopeptide repeat motifs (TRP) of Tom20 before ultimate transport to the TIM complex.