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. Author manuscript; available in PMC: 2010 Jul 1.
Published in final edited form as: Stroke. 2009 Jun 4;40(7):2307–2312. doi: 10.1161/STROKEAHA.109.554121

Table 2.

Adjusted total heritability estimates of mean and max carotid IMT overall and stratified by specific carotid segments and the covariates associated with the trait and added to the adjusted models

Trait h2 ± SE p-value Variance* Covariates
Mean Total IMT (IMTx) 0.65 ± 0.05 < 0.0001 0.51 Age, ageˆ2,sex, PackYears, WHR, BMI
Mean Bifurcation IMT (BIFx) 0.58 ± 0.05 < 0.0001 0.44 Age,ageˆ2, sex, PackYears, WHR, BMI
Mean Internal Carotid IMT (ICAx) 0.47 ± 0.05 < 0.0001 0.21 Age, ageˆ2,sex, hypercholesterolemia, WHR, BMI
Mean Common Carotid IMT (CCAx) 0.56 ± 0.05 < 0.0001 0.54 Age, sex, hypertension, diabetes, PackYears, WHR BMI
Max Total IMT (IMTm) 0.62 ± 0.05 < 0.0001 0.52 Age, ageˆ2,sex, PackYears, WHR, BMI
Max Bifurcation IMT (BIFm) 0.51 ± 0.05 < 0.0001 0.47 Age, ageˆ2, sex, age*sex, PackYears, WHR, BMI
Max Internal Carotid IMT (ICAm) 0.41 ± 0.06 < 0.0001 0.2 Age, ageˆ2, sex, PackYears, WHR, BMI
Max Common Carotid IMT (CCAm) 0.48 ± 0.05 < 0.0001 0.53 Age, sex, hypertension, hypercholesterolemia, diabetes, PackYears, WHR, BMI

WHR – waist hip ratio

BMI – body mass index

*

Proportion of variance due to all final covariates