Table 3.
SOLAR Multipoint LOD Scores > 1.5 by Trait and Ordered Subset Analyses ranking families by various systolic blood pressure and total cholesterol
| Trait | Location | CM | Marker | LOD Score | p-value | h2q | OSA % SBP > 140 (H to L) Max LOD (p-value, # family) |
OSA % SBP > 140 (L to H) Max LOD (p-value, # family) |
OSA Cholesterol (H to L) Max LOD (p-value, # family) |
OSA Cholesterol (L to H) Max LOD (p-value, # family) |
|---|---|---|---|---|---|---|---|---|---|---|
| IMTm | 14q31.1 | 95 | D14S606 | 2.3 | 0.0018 | 0.21 |
4.12 (0.0002, 69) |
2.30 (1, 100) |
2.54 (0.4055, 83) |
3.30 (0.0164, 80) |
| IMTx | 14q31.1 | 93 | D14S606 | 1.95 | 0.18 |
2.86 (0.0192, 69) |
1.95 (1, 100) |
2.21 (0.3866, 71) |
2.67 (0.056, 80) |
|
| BIFm | 3q11.2 | 119 | D3S2459 | 1.93 | 0.19 | |||||
| BIFm | 7p14.3 | 51 | D7S817 | 3.10 | 0.27 | 3.32 (0.4201, 74) |
3.13 (0.7167, 94) |
3.10 (1, 100) |
3.44 (0.2726, 97) |
|
| BIFm | 14q31.1 | 92 | D14S606 | 2.00 | 0.20 | |||||
| BIFx | 7p14.3 | 51 | D7S817 | 2.88 | 0.25 | 3.36 (0.1475, 74) |
3.09 (0.3916, 96) |
2.88 (1, 100) |
3.26 (0.221, 97) |
|
| BIFx | 14q31.1 | 95 | D14S606 | 1.63 | 0.17 | |||||
| CCAx | 5p13.3 | 45 | D5S1470 | 1.54 | 0.18 |
LOD SCORE=SOLAR multipoint LOD score
h2q=locus-specific heritability
p-value=empirical p-value based on 10,000 replicates
H to L = High to Low ranking
L to H = Low to High ranking