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. Author manuscript; available in PMC: 2010 Jun 15.
Published in final edited form as: J Immunol. 2009 Jun 15;182(12):8056–8062. doi: 10.4049/jimmunol.0801323

FIGURE 4.

FIGURE 4

Effect of IL-6 on lung neutrophil accumulation in VILI. VILI resulted in a significant increase in lung MPO activity and airspace neutrophils (PMN). Whole lung MPO activity, a measure of total neutrophil sequestration in the lung (■), was increased in IL-6-blocking Ab-treated (IL6AB) mice compared with control Ab-treated (CAB) mice, but similar in WT and IL6KO mice (n = 6 in each group; **, p < 0.05). BAL fluid neutrophil counts were significantly lower in IL6AB mice than in control Ab-treated mice (□; *, p < 0.05, n = 5 in each group) and lower in IL6KO mice and IL6-treated mice than in WT mice (†, p < 0.05, n = 5 in each group). Therefore, the ratio of total lung neutrophils to airspace lavage neutrophils was higher in IL6AB mice and IL6KO mice than in control Ab-treated and WT mice.