FIGURE 6.
Lung neutrophil accumulation in chimera mice. Whole lung MPO activity, a measure of neutrophil sequestration in the lung, was significantly higher in WT/KO mice than in WT/WT mice (■; *, p < 0.05, n = 4–5 in each group). BAL fluid neutrophil counts following VILI were significantly lower in WT/KO mice than in WT/WT mice (□; **, p < 0.05, n = 6–7 in each group). Accordingly, the ratio of total lung neutrophils to airspace lavage neutrophils was higher in WT/KO mice.