Table 1.
Mouse Lung: Significantly differentially expressing genes
| Description | *Fold change | |||
| Xenobiotic Metabolism | 1 | 2 | 3 | 4 |
| Cytochrome P450, family 1(Cyp1a1) | 24.20 | -1.02 | 26.93 | -1.11 |
| Cytochrome P450, family 1(Cyp1b1) | 7.26 | 1.05 | 7.79 | 1.05 |
| Aryl-hydrocarbon receptor repressor (Ahrr) | 2.46 | -1.04 | 3.92 | 1.13 |
| NAD(P)H dehydrogenase, quinone 1 (Nqo1) | 2.64 | 1.06 | 3.70 | -1.00 |
| Redox Balance | ||||
| Carbonyl reductase 3 (Cbr3) | 3.42 | 1.11 | 3.54 | -1.03 |
| homolog (S. cerevisiae) (Srxn1) | 1.93 | 1.04 | 3.23 | -1.06 |
| Alcohol dehydrogenase 7 (class IV)(Adh7) | 2.15 | -1.02 | 3.22 | 1.08 |
| Aldehyde dehydrogenase family 3, subfamily A1 (Aldh3a1) | 3.08 | 1.09 | 3.08 | 1.07 |
| Aldo-keto reductase family 1 | 2.03 | 1.03 | 2.34 | 1.09 |
| Thioredoxin reductase 1 (Txnrd1) | 2.06 | 1.03 | 2.32 | 1.05 |
| Aldehyde oxidase 1 (Aox1) | 1.24 | 1.08 | 2.23 | 1.16 |
| Glutathione metabolism | ||||
| Glutamate-cysteine ligase, catalytic subunit (Gclc) | 2.40 | 1.00 | 4.06 | 1.30 |
| Glutamate-cysteine ligase, modifier subunit (Gclm) | 1.87 | 1.00 | 2.14 | -1.04 |
| Glutathione reductase 1 (Gsr) | 1.31 | 1.06 | 1.34 | -1.00 |
| Glutathione S-transferase, theta 2 (Gstt2) | -1.38 | 1.08 | -1.05 | 1.12 |
| Oxidative stress, Inflammatory pathways | ||||
| Heme oxygenase (decycling) 1 (Hmox1) | 2.32 | -1.09 | 4.41 | -1.08 |
| Interleukin 6 (Il6) | 1.06 | 1.38 | 2.48 | 1.12 |
| Prostaglandin-endoperoxide synthase 2 (Ptgs2) | 1.87 | 1.47 | 2.91 | 1.13 |
| Suppressor of cytokine signaling 3 (Socs3) | 1.41 | 1.16 | 1.70 | 1.05 |
| Lectin, galactose binding, soluble 3 (Lgals3) | 1.55 | -1.09 | 1.53 | -1.11 |
| Tumor necrosis factor, alpha-induced protein 2 (Tnfaip2) | 1.53 | 1.16 | 1.30 | -1.05 |
| Paraoxonase 3 (Pon3) | 1.31 | 1.01 | 1.43 | 1.14 |
| Molecular chaperones | ||||
| Heat shock protein 1A (Hspa1a) | 2.37 | -1.22 | 2.69 | -1.46 |
| Heat shock 70 kDa protein 4 like (Hspa4l) | 1.52 | -1.01 | 1.79 | -1.03 |
| Development | ||||
| keratin complex 1, acidic, gene 19 (Krt1-19) | 1.60 | 1.05 | 1.68 | -1.02 |
| ADP-ribosylation factor related protein 2 (Arfrp2) | -1.60 | -1.02 | -1.40 | -1.08 |
| Procollagen, type V, alpha 1 (Col5a1) | -1.24 | 1.07 | -1.38 | -1.01 |
| Signal transduction pathways | ||||
| Mitogen-activated protein kinase kinase kinase 6 (Map3k6) | 1.44 | -1.12 | 1.79 | -1.17 |
| PH domain and leucine rich repeat protein phosphatase | 1.64 | -1.03 | 1.12 | -1.04 |
| Breast cancer anti-estrogen resistance 3 (Bcar3) | 1.30 | -1.10 | 1.56 | -1.02 |
| Inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (Itpa) | 1.22 | 1.08 | 1.06 | 1.01 |
| Cytoplasmic tyrosine kinase, Dscr28C related (Drosophila) (Tec) | -1.25 | -1.03 | 1.04 | 1.08 |
| Serine/threonine kinase 4 (Stk4) | 1.47 | 1.01 | -1.04 | -1.17 |
| Immediate early response 3 (Ier3) | 1.42 | 1.03 | 1.47 | -1.23 |
| Sphingosine kinase 1 (Sphk1) | 1.23 | -1.24 | 1.51 | -1.26 |
| Platelet derived growth factor receptor, beta polypeptide (Pdgfrb) | -1.42 | 1.02 | -1.50 | 1.07 |
| Transport | ||||
| Chloride channel 2 (Clcn2) | -1.39 | 1.05 | -1.07 | 1.06 |
| Solute carrier family 12, member 1 (Slc12a1) | -1.57 | 1.02 | -1.04 | 1.26 |
| Transcription | ||||
| Nuclear antigen Sp100 (Sp100) | -1.55 | 1.11 | -1.32 | 1.00 |
| Chromatin accessibility complex 1 (Chrac1) | 1.47 | 1.07 | 1.03 | -1.11 |
| X-box binding protein 1 (Xbp1) | 1.36 | -1.14 | 1.18 | -1.10 |
| TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated | 1.29 | 1.07 | 1.30 | 1.04 |
| Transcription factor E2a (Tcfe2a) | -1.29 | -1.02 | -1.35 | -1.08 |
| Structure | ||||
| LIM-domain containing, protein kinase (Limk1) | 1.49 | 1.06 | 1.30 | -1.14 |
| DIX domain containing 1 (Dixdc1) | -1.31 | 1.20 | -1.41 | 1.16 |
| Ankyrin 3, epithelial (Ank3), transcript variant 1 | -1.14 | 1.09 | -1.27 | 1.10 |
| Oncogene, tumour suppressor | ||||
| B-cell leukemia/lymphoma 3 (Bcl3) | 1.73 | 1.00 | 2.13 | -1.15 |
| T-cell lymphoma invasion and metastasis 1 (Tiam1) | -1.19 | 1.13 | -1.45 | 1.10 |
| Kruppel-like factor 9 (Klf9) | 1.02 | -1.47 | 1.01 | -1.32 |
| Others | ||||
| Growth arrest and DNA-damage-inducible 45 gamma (Gadd45g) | 1.21 | -1.01 | 1.95 | -1.18 |
| Enoyl Coenzyme A hydratase domain containing 3 (Echdc3) | -1.50 | 1.13 | -1.12 | 1.13 |
| Cathepsin D (Ctsd) | 1.54 | -1.05 | 1.46 | 1.03 |
| Angiomotin like 2 (Amotl2) | 1.47 | 1.15 | -1.02 | -1.02 |
| Glucose-6-phosphate dehydrogenase X-linked (G6pdx) | 1.42 | -1.00 | 1.20 | -1.05 |
| TG interacting factor (Tgif) | -1.06 | 1.07 | 1.33 | -1.01 |
| Nucleolar protein 5A (Nol5a) | 1.31 | 1.02 | 1.03 | -1.10 |
| Protein-O-mannosyltransferase 1 (Pomt1) | -1.24 | 1.02 | -1.03 | 1.05 |
| Chitinase 3-like 3 (Chi3l3) | 3.19 | -1.12 | 2.91 | 1.25 |
| Leukotriene C4 synthase (Ltc4s) | 1.81 | -1.06 | 1.19 | 1.10 |
| ATPase, H+ transporting, V0 subunit D, isoform 2 (Atp6v0d2) | 1.76 | -1.15 | 1.58 | -1.13 |
| Cold inducible RNA binding protein (Cirbp) | -1.48 | 1.14 | -1.58 | 1.06 |
| Unknown and RIKENS | ||||
| Lung-inducible neuralized-related C3HC4 RING domain protein (Lincr) | 1.45 | 1.08 | 1.22 | -1.04 |
| Selenocysteine lyase (Scly) | -1.29 | 1.14 | -1.26 | 1.00 |
| RIKEN cDNA B230118H07 gene | -1.07 | 1.08 | -1.29 | 1.12 |
| RIKEN cDNA 1110019L22 gene | 1.13 | 1.02 | -1.22 | -1.27 |
| Zinc finger CCCH type, antiviral 1 (Zc3hav1) | -1.33 | -1.06 | -1.18 | -1.02 |
| RIKEN cDNA 9830165K03 | -1.40 | 1.12 | -1.18 | 1.02 |
| RIKEN cDNA 2310007H09 gene | -1.38 | 1.11 | -1.07 | 1.11 |
| mRNA for mKIAA1201 protein | -1.31 | 1.09 | -1.36 | 1.00 |
| Oolfactory receptor 1286 (Olfr1286) | -1.87 | 1.17 | 1.06 | -1.04 |
| Procollagen, type III, alpha 1 (Col3a1) | -1.59 | -1.05 | -1.77 | 1.17 |
| RIKEN cDNA 1190002H23 gene | -1.25 | -1.14 | 1.73 | -1.06 |
| 4 days neonate male adipose cDNA, RIKEN | 1.23 | -1.54 | 1.15 | -1.70 |
| Roundabout homolog 2 (Drosophila) (Robo2) | -1.66 | 1.04 | -1.18 | 1.22 |
| Adult male urinary bladder cDNA, RIKEN | 1.11 | 1.12 | -1.04 | -1.64 |
| RIKEN cDNA 1700012B18 gene | 1.33 | -1.23 | 2.25 | -1.21 |
| Btg3 associated nuclear protein (Banp) | -1.36 | -1.48 | 1.16 | 1.06 |
| RIKEN cDNA 9130213B05 gene | 1.39 | 1.00 | 1.52 | -1.01 |
| E74-like factor 3 (Elf3) | 1.51 | 1.03 | 1.47 | 1.06 |
* 1. 6 weeks smoke, 2. 6 weeks smoke followed by 6 weeks break, 3. 12 weeks smoke
4. 12 weeks smoke followed by 6 weeks break