Figure 5.
The MR N/C-interaction in LLC-PK1 (A), H9C2 (B), COV-434 (C), and HEK293 (D) cells. The cells were transiently cotransfected with GAL4-MRC with or without VP16-MRNT in the presence or absence of aldosterone (10 nm). Luciferase activity is represented as fold activation relative to luciferase activity in the absence of ligand. Each data point represents the mean ± sem derived from three independent experiments; *, P < 0.001; and ***, P < 0.05 denote significance when compared with aldosterone in the absence of MRNT.