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. 2009 Jun 18;23(9):1360–1370. doi: 10.1210/me.2009-0032

Figure 7.

Figure 7

Structural determinants of the MR N/C-interaction in the NTD. COS-1 cells were transiently cotransfected with GAL4-MRC(E962A) with or without VP16-MRNT and with a series of deletions of VP16-MRNT as indicated in panels A and B. The cells were treated with vehicle (open bars) or aldosterone (10 nm) (solid bars). Each data point represents the mean ± sem derived from three independent experiments; *, P < 0.001 denotes significance when compared with wild type [VP16-MRNT (1–597) + MRC(E962A)] in the presence of aldosterone; ♦, P < 0.01; and †, P < 0.001 denote significance when compared with vehicle alone. C, Schematic representation of N/C-interaction between fragments of MRNT and MRC(E962A).