Table 1.
Substrates of HMTs and demethylases involved in nuclear hormone signaling
| Enzyme | Effector of | Substrates
|
||
|---|---|---|---|---|
| Histone | NR | Coregulator | ||
| HMTs | ||||
| Arginine | ||||
| CARM1 (PRMT4) | ER, AR, TR, PPARγ | H3R2, H3R17, H3R26 | SRC-3, CBP/p300 | |
| PRMT1 | ER, AR, TR, HNF | H4R3 | ER, HNF4 | PGC-1α, RIP140 |
| Lysine | ||||
| EZH2 | ER | H3K27 | ||
| ESET | ER, AR | H3K9 | ||
| RIZ1 | ER, AR | H3K9 | ||
| G9a | ER | H3K9 | ||
| SUV39H | TR | H3K9 | ||
| EuHMTase | ER | H3K9 | ||
| MLL3 | LXR | H3K4 | ||
| MLL4 | LXR | H3K4 | ||
| Set7/9 | H3K4 | ER | ||
| HDMTs | ||||
| Arginine | ||||
| PADI4 | ER | H3R2, H3R17, H3R26 | CBP/p300 | |
| Lysine | ||||
| LSD1 | ER, AR | H3K4, H3K9 | ||
| JHDM2A/KDM3A | AR, PPARγ, RXRα | H3K9 | ||
| JHDM3A/KDM4A | AR | H3K9, H3K36 | ||
| JHDM3C/KDM3C | AR, GR, PR | H3K9, H3K36 | ||
HNF4, Hepatocyte nuclear factor 4; LXR, Liver X receptor; PR, progesterone receptor; RXR, retinoid X receptor.