Table 1.
Enzyme | Effector of | Substrates
|
||
---|---|---|---|---|
Histone | NR | Coregulator | ||
HMTs | ||||
Arginine | ||||
CARM1 (PRMT4) | ER, AR, TR, PPARγ | H3R2, H3R17, H3R26 | SRC-3, CBP/p300 | |
PRMT1 | ER, AR, TR, HNF | H4R3 | ER, HNF4 | PGC-1α, RIP140 |
Lysine | ||||
EZH2 | ER | H3K27 | ||
ESET | ER, AR | H3K9 | ||
RIZ1 | ER, AR | H3K9 | ||
G9a | ER | H3K9 | ||
SUV39H | TR | H3K9 | ||
EuHMTase | ER | H3K9 | ||
MLL3 | LXR | H3K4 | ||
MLL4 | LXR | H3K4 | ||
Set7/9 | H3K4 | ER | ||
HDMTs | ||||
Arginine | ||||
PADI4 | ER | H3R2, H3R17, H3R26 | CBP/p300 | |
Lysine | ||||
LSD1 | ER, AR | H3K4, H3K9 | ||
JHDM2A/KDM3A | AR, PPARγ, RXRα | H3K9 | ||
JHDM3A/KDM4A | AR | H3K9, H3K36 | ||
JHDM3C/KDM3C | AR, GR, PR | H3K9, H3K36 |
HNF4, Hepatocyte nuclear factor 4; LXR, Liver X receptor; PR, progesterone receptor; RXR, retinoid X receptor.