Supplementary Table B.
Clinical and Biological Characteristics of Narcoleptics with Long Night Time Sleep (Total Night Time Sleep During the Second Night > 10 Hours) Compared with Patients with Narcolepsy without Long Night Time Sleep, Idiopathic Hypersomnia with Long Night Time Sleep and Controls
| Patients | Narcolepsy with long night time sleep | Narcolepsy without long night time sleep | Idiopathic hypersomnia with long night time sleep | Controls |
|---|---|---|---|---|
| Number | 12 | 28 | 25 | 20 |
| Age, y | 23.8 ± 6.7 | 31.2 ± 10.1 * | 29.6 ± 12.5 | 29.4 ± 8.7 * |
| Body mass index, kg/m2 | 24.1 ± 5.0 | 24.8 ± 6.1 | 23.2 ± 3.6 | 23.9 ± 4.8 |
| Women, % | 67 | 50 | 72 | 65 |
| Hypnagogic hallucinations, % | 64 | 68 | 32 | 10 * |
| Sleep paralysis, % | 36 | 47 | 37 | 0 * |
| Non refreshing naps, % | 50 | 60 | 59 | 0 * |
| Sleep drunkenness, % | 60 | 42 | 72 | 0 * |
| Clear-cut cataplexy, % | 18 | 46 | 0 * | 0 * |
| HLA DQB1*0602 positive, % | 50 | 52 | 30 | 10 * |
| Core narcolepsy, %† | 8 | 29 | NA | NA |
| Epworth Sleepiness score (0–24) | 15.1 ± 2.1 | 17.1 ± 3.4 | 15.1 ± 4.5 | 5.8 ± 2.0 * |
| Fatigue Severity Score (0–70) | 48.9 ± 8.3 | 55.1 ± 6.3 | 51.1 ± 10.7 | 31.6 ± 9.2 * |
| Pichot Fatigue Score (0–32) | 27.4 ± 7.1 | 27.2 ± 7.2 | 24.9 ± 9.0 | 11.0 ± 3.5 * |
| HAD anxiety (0–21) | 9.1 ± 6.1 | 10.7 ± 4.0 | 9.5 ± 4.5 | 5.6 ± 3.3 |
| HAD depression (0–21) | 6.9 ± 2.7 | 5.2 ± 2.8 | 6.4 ± 5.0 | 3.9 ± 2.8 * |
| Horne-Ostberg score | 48.2 ± 7.6 | 46.1 ± 14.7 | 39.3 ± 13.4 * | 54.8 ± 7.6 |
†
Core narcolepsy: simultaneous presence of clear-cut cataplexy and HLA DQB1*0602 positivity, which yields a 88-93% sensitivity for hypocretin deficiency.
*
P<0.05 for a difference between narcolepsy with long sleep time, HLA: human leukocyte antigen; HAD: score at the hospital anxiety and depression scale