Table 2.

Aggregation of System Abnormalities and Joint Association With Frailty. (A) Multisystem Deficit Profile: Conditional Probabilities of Meeting Deficit Criteria Within Latent Classes (N = 704) and (B) Independent Association of Class 2 Cluster of 2.9 System Abnormalities, on Average, With Frailty (compared with class 1 cluster with 1.3 system abnormalities)^*

A
		1-Class Model	2-Class Model
System	Measure	Class 1	Class 1	Class 2
Prevalences of abnormal level of each measure
Anemia	Hemoglobin <12 g/dL	0.131	0.071	0.267
Inflammation	IL-6 >4.6 pg/mL	0.253	0.153	0.485
Endocrine	IGF-1 <74.3 ng/mL	0.174	0.137	0.257
	DHEA-S <0.215 mcg/mL	0.244	0.217	0.307
Glucose tolerance	Hemoglobin A1c ≥6.5%	0.234	0.192	0.329
Micronutrient	≥2 micronutrient deficits	0.225	0.188	0.311
Body composition	Skinfold thickness <17 mm	0.247	0.211	0.328
Fine motor speed	Purdue Pegboard >31.9 s	0.237	0.089	0.577
Class prevalence (%)		100	69.6	30.4
Mean number of systems abnormal		1.7	1.3	2.9
Model fit statistics	LR chi square	293.5 (p < .01)	244.1 (p = .19)
	AIC	5,573.9	5,534.1
	BIC	5,685.0	5,557.6
B
		Frail vs Nonfrail OR (95% CI)
Age		1.15 (1.04–1.28)†
Black race		1.75 (0.92–3.31)
Education (y)		0.81 (0.74–0.89)†
Number of diseases‡		2.42 (1.89–3.10)†
Multiple (ie, class 2) vs isolated abnormalities (ie, class 1)		2.59 (1.22–5.52)§

Notes: AIC = Akaike information criterion; BIC = Bayesian information criterion; CI = confidence interval; LR= Likelihood Ratio; OR = odds ratio.

^*Results of polytomous multinomial logistic regression based on repeated generation of “pseudo” classes of multisystem impairments using posterior latent class probabilities.

^†p value <.01.

^‡Number of adjudicated “definite” chronic conditions of 11: coronary artery disease (angina pectoris and/or myocardial infarction), congestive heart failure; peripheral arterial disease; stroke; pulmonary disease; hip fracture; diabetes mellitus; osteoarthritis of the knee, hip, and hand; rheumatoid arthritis; Parkinson’s disease; and cancer.

^§p value<.05.