Table 3.
Characteristics of the 10 Studies on Rodents
| Author, Publication Year* (reference) | Species | Age at OVX | Number of Animals (intact/OVX/OVX+estradiol) | Estradiol Treatment | Study Duration (wk) |
| Suzuki and Yamamuro, 1985 (48) | Wistar rats | 3 wk | 6/6/6 | 20 mg, 2×/wk, sc injection | 7 |
| McCormick et al., 2004 (49) | Sprague Dawley rats | 7 wk | 8/8/9 | sc implant of silastic tube | 4 |
| Fisher et al., 1998 (50) | Sprague Dawley rats | 6–7 mo | 8/10/— | — | 4 |
| Wohlers et al., 2009 (51) | C57BL/6 mice | 8 wk | 5/5/— | — | 8 |
| Hubal et al., 2005 (52) | ICR mice | 13 wk | 12/9/— | — | 8 |
| Moran et al., 2007 (53) | C57BL/6 mice | 4 mo | 20/31/18 | 0.18 mg, 60-d release pellets | 8 |
| Schneider et al., 2004 (54) | C57BL/6 mice | <8 wk | 13/13/9 | 0.05 mg, 21-d release pellets | 2.5 |
| Warren et al., 1996 (55) | ICR mice | 6 wk | —/8/8 | 40 mg/kg/d, sc injection | 3 |
| Moran et al., 2006 (25) | C57BL/6 mice | 6 mo | 10/13/— | — | 8 |
| Wattanapermpool and Reiser, 1999 (56) | Sprague Dawley rats | 8–10 wk | 3/3/— | — | 14 |
Notes: OVX = ovariectomy; sc = subcutaneous.
*
Studies are arranged corresponding to Figure 4.