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. 2009 Sep 15;4(9):e6984. doi: 10.1371/journal.pone.0006984

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Dawson et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A. M tuberculosis sputum smear conversion. At 4 weeks, there was a higher Mtb smear conversion rate in the NEB rIFN-γ1b group compared to DOTS and subcutaneous IFN-γ1b plus DOTS (p = 0.03). At enrollment, all sputa were Mtb smear and culture positive. Y axis represents 1- probability of conversion in a Kaplan-Meier curve. B. Change in fever over 16 weeks comparing DOTS (dashed line) to DOTS plus nebulized rIFN-γ1b group (solid line). rIFN-γ1b significantly (p<0.05) reduced subjective fever at 4 weeks. Y axis represents proportion of patients having fever.