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. 2009 Sep 16;4(9):e7046. doi: 10.1371/journal.pone.0007046

Figure 2. PPARδΔAF2 represses (A) PPARδ and (B) PPARγ1 signalling. (C) PPARδΔAF2 represses TK-promoter activity in a ligand-enhanced fashion.

Figure 2

COS-1 cells were transiently transfected with (per well in six-well plates) (A) 50 ng pCLDN-hPPARδ or (B) pCDLN-hPPARγ1 and 250 ng pCLDN or pCLDN-hPPARδΔAF2. (C) and (D) T47D cells were transfected with (per well in a six-well plate) 500 ng pCLDN, pCLDN-hPPARδΔAF2 or pCLDN-hPPARδ. (D) is identical to (C) except for the two additional bars representing over-expression of PPARδ with and without CF.