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The protective effect of glycine-proline-glutamate (GPE) after hypoxia-ischemia injury in rats. A single i.v. bolus injection of GPE (3 mg·kg−1) followed by a continuous 4 h i.v. infusion of GPE (3 mg·kg·h−1) given 1–5 h after injury. Histology examined after 4 days. The group with GPE treatment significantly reduced the degree of brain damage compared to the group treated with the vehicle. Cx, lateral cortex, DG, dentate gyrus. *P < 0.05.
