Figure 1.
Effects of urocortin 1 on blood glucose, insulin level, kidney weight, Ccr and albuminuria of DN rats. Blood glucose (A) and insulin (B) level were not affected; however, average kidney weight (C) was decreased by urocortin 1. Ccr (D) was enhanced, and 24 h urinary albumin excretion (E) was decreased by urocortin 1 treatment. Astressin blunted the effect of urocortin 1. *P < 0.05, **P < 0.01 compared with DN; ##P < 0.01 compared with DN + ucn; $P < 0.05, $$P < 0.01 compared with normal. n= 10.Normal, non-diabetic control; DN, untreated diabetic; DN + ucn, diabetic rats treated with urocortin 1 (6 µg·kg−1); DN + ucn/ast, diabetic rats treated with urocortin 1 + astressin (6 µg·kg−1 and 30 µg·kg−1 respectively,). Ccr, creatinine clearance rate; DN, diabetic nephropathy.