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. 2009 Jun 5;157(6):1014–1023. doi: 10.1111/j.1476-5381.2009.00292.x

Figure 8.

Figure 8

Effects of tripterine on the phosphorylation of Jak2, ERK and JNK, and the degradation of IκB. Endothelial cells were pretreated with vehicle or 50, 200 nM and 1 µM tripterine for 2 h, and then incubated with the same drugs and either LPS + IFNγ or vehicle for another 30 min for Western blot analysis. (A) Western blot examples for pJak2, pERK, pJNK, total IκB and β-actin. (B), (C), (D) and (E) The summaries of the band intensity of pJak2, pERK, pJNK and total IκB (n = 3) respectively. *P < 0.05 compared with vehicle control; #P < 0.05 compared with LPS + IFNγ. IFNγ, interferon γ; LPS, lipopolysaccharide; pERK, phosphorylated extracellular-regulated kinase; pJak2, phosphorylated Janus kinase 2; pJNK, phosphorylated c-Jun terminal kinases.