Table 9.
List of selected genes that are functionally related to cell cycle regulation and DNA damage and were changed by 15-methoxypinusolidic acid treatment
| Gene ID | Gene symbol | Protein name | Fold change | Function |
|---|---|---|---|---|
| 496423 | gadd45α | Growth arrest and DNA damage-inducible protein GADD45 α | 14.62 | Binds to proliferating cell nuclear antigen; might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase |
| 422947 | ddit3 | DNA damage-inducible transcript 3 | 7.39 | Inhibits the DNA-binding activity of C/EBP and LAP by forming heterodimers that cannot bind DNA |
| 807657 | cdkn2b | Cyclin-dependent kinase 4 inhibitor B (p14-INK4b, p15-INK4b) | 6.77 | Interacts strongly with CDK4 and CDK6; potent inhibitor; potential effector of TGF-β-induced cell cycle arrest |
| 930147 | gadd45γ | Growth arrest and DNA damage-inducible protein GADD45 γ | 2.07 | Involved in the regulation of growth and apoptosis; mediates activation of stress-responsive MTK1/MEKK4 MAPKKK |
| 463565 | fos | Proto-oncogene protein c-fos | 0.49 | Nuclear phosphoprotein that forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor; has a critical function in regulating the development of cells destined to form and maintain the skeleton; it is thought to have an important role in signal transduction, cell proliferation and differentiation |
| 534427 | jun | Transcription factor AP-1 | 0.49 | Transcription factor that recognizes and binds to the enhancer heptamer motif 5′-TGA[CG]TCA-3′ |
| 911031 | mcm4 | DNA replication licensing factor MCM4 | 0.49 | Involved in the control of DNA replication |
| 580590 | orc1l | Origin–recognition complex subunit 1 | 0.44 | Component of the origin–recognition complex that binds origins of replication; it has a role in both chromosomal replication and mating type transcriptional silencing; binds to the ARS consensus sequence of origins of replication in an ATP-dependent manner |
| 466841 | ccne1 | G1/S-specific cyclin E1 | 0.37 | Essential for the control of the cell cycle at the G1/S (start) transition |
| 352483 | ccnd3 | G1/S-specific cyclin D3 | 0.35 | Essential for the control of the cell cycle at the G1/S (start) transition; potentiates the transcriptional activity of ATF5 |
| 684806 | ccnd1 | G1/S-specific cyclin D1 | 0.31 | Essential for the control of the cell cycle at the G1/S (start) transition |
| 579729 | cdc6 | Cell division control protein 6 homologue | 0.24 | Involved in the initiation of DNA replication; also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated |