Plasma concentrations (ng·mL−1) of morphine and M3G after 1 mg·kg−1 morphine given as a 10 min constant infusion. In A, results from control premature lambs and in B, results from adult sheep. In C, values from adults, premature lambs and premature asphyxial lambs are shown. M3G, morphine-3-glucuronide.