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Unbound M3G concentrations (ng·mL−1) in the blood and cortex ISF after 1 mg·kg−1 morphine given as a 10 min constant infusion. In A, results from premature control lambs and in B, results from adult sheep. In C, values from adults, premature control lambs and premature asphyxial lambs are shown. ISF, interstitial fluid; M3G, morphine-3-glucuronide.
