Table 2.
Relative recovery of morphine and M3G from microdialysis probes in sheep and lambs
|
Adult sheep |
Premature lambs |
||
|---|---|---|---|
| (n =6) | Control (n =6) | Asphyxial (n =5) | |
| Morphine | |||
| Blood | 0.71 (0.10)–0.45 (0.09)a | 0.80 (0.05) | 0.84 (0.05) |
| Brain | 0.13 (0.05) | 0.32 (0.10) | 0.36 (0.16) |
| M3G | |||
| Blood | 0.56 (0.08)–0.32 (0.07)a | 0.63 (0.06) | 0.68 (0.06) |
| Brain | 0.052 (0.02) | 0.20 (0.19) | 0.21 (0.16) |
a
Decreased throughout the study.
Recovery was calculated as described in Methods. Values in the table are means (SD) from the number of animals shown (n).
M3G, morphine-3-glucuronide.