Table 3.
Pharmacokinetic parameters presented as mean values (SD) for morphine and M3G in adult sheep, and in control and asphyxial premature lambs
|
Adult sheep |
Premature lambs |
||||
|---|---|---|---|---|---|
| Control (n =6) | Control (n =6) | Asphyxial (n =5) | P value |
||
| Control groupsa | Lamb groupsb | ||||
| Morphine | |||||
| CL (mL·min−1·kg−1) | 34.3 (8.5)c | 20.3 (6.6) | 18.4 (2.5) | 0.013 | 0.549 |
| Vβ (L·kg−1) | 6.38 (0.90)c | 2.74 (0.52) | 2.45 (0.45) | 0.00001 | 0.354 |
| Kpuu | 1.19 (0.20) | 1.89 (0.51) | 1.80 (0.68) | 0.018 | 0.811 |
| Vubrain (mL·g−1) | 3.15 (0.34)c | 1.76 (0.47) | – | 0.002 | |
| t1/2 blood probe (min) | 119 (23) | 78 (23) | 83 (17) | 0.011 | 0.700 |
| t1/2 cortex probe (min) | 320 (87)d | 157 (47)d | 140 (27)d | 0.002 | 0.486 |
| Residual area blood probe (%) | 5.5 (2.0) | 9.5 (6.2) | 10.6 (4.8) | ||
| Residual area cortex probe (%) | 44.3 (7.6) | 35.4 (9.3) | 32.2 (6.6) | ||
| M3G | |||||
| Kpuu | 0.27 (0.16) | 0.17 (0.15) | 0.24 (0.21) | 0.251 | 0.527 |
a
T-test comparing adult sheep with the premature control groups.
b
T-test comparing the premature lamb groups.
c
Based on five individuals.
d
T-test comparing t1/2 in cortex and blood (P values were 0.0008, 0.0008 and 0.0118 for adults, the premature control group and the premature asphyxial group respectively).
–, not estimated; M3G, morphine-3-glucuronide.