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. Author manuscript; available in PMC: 2009 Sep 4.
Published in final edited form as: Ann Surg Oncol. 2008 Jun 18;15(9):2600–2605. doi: 10.1245/s10434-008-0006-z

Figure 5.

Figure 5

SBHA regulates the expression of apoptotic mediators and induces caspase-dependent apoptosis in a mouse model of MTC. Western blot analysis was performed for the levels of apoptotic mediators utilizing tumor tissue lysates. (A) SBHA treatment resulted in increased caspase-9, caspase-3 and PARP cleavage, indicating activation of the apoptotic pathway. (B) After SBHA treatment, the antiaopototic proteins Bcl-2 and Bcl-XL were markedly down-regulated. In contrast, the expression levels of proapoptotic proteins Bad, Bmf and Bax were up-regulated. G3PDH was used to confirm equal protein loading.