Table 3.

Spearman correlations between psychometric test scores at last assessment and plaque burden, counts of diffuse plaques, and NFT density for participants with those lesions.

	MMSE			Logical Memory Delayed			Trailmaking A			Trailmaking B			Boston Naming		Category Fluency			Digit Symbol
	N	r		N	r		N	r		N	r		N	r	N	r		N	r
Plaque Burden
Limbic	55	.06		24	−.48	*	42	.34	*	31	.21		38	.07	42	−.12		20	−.09
Neocortex	53	−.02		23	−.53	*	41	.50	***	31	.25		36	.01	39	−.21		19	.10
Diffuse SPs
Limbic	44	−.29		18	−.58	*	36	.15		26	.41	*	30	.02	32	−.23		16	−.30
Neocortex	46	.02		18	−.54	*	38	.38	*	28	.14		31	−.11	35	−.25		17	.12
NFTs
Limbic	68	−.36	**	27	−.01		56	−.19		43	.00		49	−.14	53	−.03		28	.33
Neocortex	17	−.01		3	NA		20	−.27		12	.44		17	.05	15	−.56	*	12	.24

^*p<.05;

^**p<.01;

^***p<.001

Abbreviations: SE = Standard Error, MMSE = Mini-Mental State Test, SP = senile plaques, NFT = neurofibrillary tangles

Better cognitive functioning is indicated by higher scores for the MMSE, Logical Memory Delayed, Category Fluency, Digit Symbol, and Boston

Naming test and by lower scores on Trailmaking A and Trailmaking B tests.