Table 2.

Mean therapeutic and algorithm-predicted warfarin doses in the index patient.

Warfarin dose	mg/week	Ref.
Mean therapeutic dose	14.4	–
Algorithm-predicted dose‡
Sconce et al. (2005)	47.6	[41]
Wadelius et al. (2005)	49.7	[21]
Herman et al. (2006)	42.5	[51]
Takahashi et al. (2006)	50.3	[5]
Tham et al. (2006)	32.9	[52]
Anderson et al. (2007)	45.8	[53]
Miao et al. (2007)	49.1	[54]
Zhu et al. (2007)	52.2	[40]
Gage et al. (2008)	34.6	[16]
Schelleman et al. (2008) (C)	41.9	[17]
Schelleman et al. (2008) (AA)	28.4	[17]
Schelleman et al. (2008) (C + AA)	41.5	[17]
Wu et al. (2008)	24.9	[20]
Klein et al. (2009)	35.4	[6]
Wadelius et al. (2009)	50.1	[22]

^‡Based on the following genotypes: CYP2C9: *1/*1; VKORC1 (Accession Number AY587020) g.-4931T>C (381T>C): T/C, g.-1639G>A (3673G>A): G/G, g.1173C>T (6484C>T): C/C, g.2255C>T (7566C>T): C/T, g.3730G>A (9041G>A): G/G; F7 g.-401G>T: G/G; APOE: ε2/ε3.

AA: African–American; C: Caucasian.