Table 4.
African–American CYP2C9 genotype frequencies (n = 300).
| Predicted metabolizer phenotype/genotype | Number of subjects | Observed (expected‡) frequency (%) |
|---|---|---|
| Extensive metabolizer | ||
| *1/*1 | 227 | 75.7 (75.1) |
| Intermediate metabolizer | ||
| *1/*2 | 13 | 4.3 (4.9) |
| *1/*3 | 10 | 3.3 (3.5) |
| *1/*5 | 8 | 2.7 (2.6) |
| *1/*6 | 5 | 1.7 (1.7) |
| *1/*8 | 26 | 8.7 (8.1) |
| *1/*11 | 6 | 2.0 (2.3) |
| Total | 68 | 22.7 (23.1) |
| Poor metabolizer | ||
| *2/*2 | 1 | 0.3 (0.1) |
| *2/*3 | 1 | 0.3 (0.1) |
| *3/*11 | 1 | 0.3 (0.1) |
| *5/*6 | 1 | 0.3 (0.0) |
| *8/*11 | 1 | 0.3 (0.1) |
| Total | 5 | 1.7 (0.4) |
‡
Predicted Hardy–Weinberg frequencies.