Skip to main content
. Author manuscript; available in PMC: 2009 Sep 4.
Published in final edited form as: Eur J Immunol. 2009 Jun;39(6):1652–1663. doi: 10.1002/eji.200838135

Figure 4.

Figure 4

IL-4 promotes T cell priming in experimental anesthetic DILI. After 72h, proliferation to (A) CYP2E1 and (B) TFA was significantly higher in WT splenocytes when compared to KO mice at all CYP2E1 or TFA doses (**p<0.01, ***p<0.001, Mann-Whitney U. Mean ± SEM of pooled data from individual mice. Experiments were run in triplicate with N = 5 mice/group). Supernatants from (C) CYP2E1-stimulated KO splenocyte cultures had significantly elevated concentrations of IL-2, IL-6, IL-10 and IFN-γ (*p<0.05, ***p<0.001 while (D) TFA-stimulated KO splenocyte cultures had significantly lower concentrations of IL-1β, IL-2, IL-6, IL-13 and IFN-γ, when compared to WT cultures (*p<0.05, **p<0.01, Mann-Whitney U. Mean ± SEM of pooled data from individual mice. Experiments were run in duplicate with N = 5 mice/group).