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. Author manuscript; available in PMC: 2009 Sep 4.
Published in final edited form as: Annu Rev Nutr. 2008;28:347–366. doi: 10.1146/annurev.nutr.28.061807.155354

Figure 1.

Figure 1

Interactions between histone-modifying enzymes and histone modifications associated with the silencing of gene expression. DNA methylation catalyzed by DNA methyl transferases and methyl-binding domain proteins can recruit histone deacetylases and histone methyl transferases that further repress gene transcription. DNMT, DNA methyltransferase; HDAC, histone deacetylase; HP, histone-binding protein; PRC, Polycomb repressive complexes; Suv, suppressor of variegation; SWI/SNF, switch/sucrose nonfermentable.