Skip to main content
. Author manuscript; available in PMC: 2009 Sep 4.
Published in final edited form as: Angew Chem Int Ed Engl. 2008;47(38):7358–7362. doi: 10.1002/anie.200802910

Table 4.

Synthesis and in situ use of aryl aluminum reagents in coppercatalyzed ACA.[a]

graphic file with name nihms110606t4.jpg
Entry NHC–AgI Substrate Conversion [%][b] e.r.[c] ee [%][c]
1 1 6c >98 68.5:31.5 37
2 2 6c >98 73.5:26.5 47
3 3 6c >98 50:50 <2
4 4 6c >98 34:66 −32
5 5 6c >98 46.5:53.5 −7
6 1 8a >98 64:36 28
7 2 8a >98 89:11 78
8 3 8a >98 38:62 −24
9 4 8a >98 26:74 −48
10 5 8a >98 42.5:57.5 −15
[a–c]

See Table 1. Three equivalents of the aluminum-based reagent were used.