Table 5.

Copper-catalyzed ACA of aryl aluminum reagents to β-substituted cyclic enones.^[a]

Entry	Substrate	Ar	T [°C]	t [h]	Yield [%][b]	e.r.[c]	ee [%][c]
1	6c	C6H5	−50	48	66	86:14	72
2	6c	oMeC6H4	−15	48	85	99:1	98
3	6c	pOMeC6H4	−50	48	67	85.5:14.5	71
4	6c	oOMeC6H4	−15	48	55	97.5:2.5	95
5	8a	C6H5	−30	36	71	95:5	90
6	8a	oMeC6H4	+4	42	49	98:2	96
7	8a	pOMeC6H4	−50	36	61	92:8	84
8	8a	pCF3C6H4	−30	36	52	93:7	86
9	8a	oOMeC6H4	+4	48	60	88:12	83

^[a–c]See Table 2. [c] Determined by chiral GLC or HPLC analysis (see the Supporting Information for additional details).