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. Author manuscript; available in PMC: 2009 Sep 4.

Published in final edited form as: J Pharmacokinet Pharmacodyn. 2009 Jan 21;36(1):1–18. doi: 10.1007/s10928-008-9107-3

Table 2.

PK parameters estimate for KETO and MDZ

KETO			MDZ

Parameter	Est.	95% CI	Parameter	Est.	95% CI
V1_I	20.1	(0.84, 1.17)	V1_S	67.05	(0.73, 1.59)
V2_I	32.2	(0.56, 1.85)	V2_S	45.08	(0.65, 1.55)
V max_I	21.0	(0.83, 1.17)	V max_S	4284	(0.63, 1.43)
Km_I	0.48	(0.97, 1.06)	Km_S	2.11	(0.60, 1.80)
CL12_I	2.25	(0.54, 1.78)	CL12_S	42.9	(0.56, 1.60)
ka_I,TM	0.45	(0.78, 1.40)	ka_S,SL	1.86	(0.44, 2.29)
ka_I,TF	0.70	(0.78, 1.42)	ka_S,T	0.69	(0.09, 4.02)
ka_I,SPF	1.79	(0.76, 1.41)	Fa_S,SL	0.46	(0.55, 1.70)
ka_I,SLM	0.75	(0.74, 1.41)	Fa_S,T	0.24	(0.38, 2.13)
ka_I,SLF	2.18	(0.74, 1.44)	ω_{F_S}	0.29	(0.26, 2.23)
ω_{V1_I}	0.14	(0.40, 1.94)	ω_{V1_S}	0.39	(0.29, 1.57)
ω_{V2_I}	0.64	(0.43, 1.68)	ω_{V2_S}	0.43	(0.31, 1.66)
ω_{V max_I}	0.15	(0.52, 1.72)	ω_{V max_S}	0.36	(0.37, 1.44)
ω_{CL12_I}	0.72	(0.59, 1.74)	ω_{CL12_S}	0.43	(0.36, 1.58)
ω_{ka_I}	0.38	(0.47, 1.76)	ω_{ka_S}	0.36	(0.28, 2.28)