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. Author manuscript; available in PMC: 2009 Sep 4.
Published in final edited form as: J Pharmacokinet Pharmacodyn. 2009 Jan 21;36(1):1–18. doi: 10.1007/s10928-008-9107-3

Table 3.

Population average DDI prediction

Ki KETO (mg)/MDZ (mg)
200/2 800/10
0.18 1.21 ×/÷ 1.013 1.78 ×/÷ 1.027
0.0037 3.02 ×/÷ 1.11 3.93 ×/÷ 1.14

Geometric mean ×/÷ (1 + CV) of the predicted AUCR