Table 2. Pharmacokinetics Parameter Estimates for KETO and MDZ.
| Parameters | Methods | ||||
|---|---|---|---|---|---|
| Model 2* | Model 1** | ||||
| Estimate | 90% CI*** | Estimate | 90% CI*** | ||
| KETO: | |||||
| V1I | 20.6 | (16.0, 24.6) | 21.3 | (17.5, 26.0) | |
| V2I | 24.4 | (16.3, 37.0) | 33.8 | (17.9, 44.6) | |
| V maxI | 23.1 | (20.1, 26.4) | 22.2 | (18.0, 26.9) | |
| CL12I | 3.22 | (2.53, 4.04) | 2.10 | (1.10, 3.78) | |
| kaI,TM | 0.42 | (0.37, 0.48) | 0.45 | (0.33, 0.65) | |
| kaI,TF | 0.61 | (0.42, 1.10) | 0.72 | (0.53, 1.07) | |
| kaI,SPF | 2.03 | (1.55, 2.35) | 1.79 | (0.95, 1.92) | |
| kaI,SLM | 0.70 | (0.60, 0.98) | 0.76 | (0.58, 1.10) | |
| kaI,SLF | 2.72 | (2.33, 3.14) | 2.23 | (1.65, 3.32) | |
| ωV1I | 0.22 | (0.10, 0.42) | 0.13 | (0.06, 0.26) | |
| ωV2I | 0.44 | (0.23, 0.81) | 0.66 | (0.33, 1.14) | |
| ωVmaxI | 0.17 | (0.10, 0.29) | 0.15 | (0.08, 0.26) | |
| ωCL12I | 0.54 | (0.35, 1.34) | 0.77 | (0.40, 1.37) | |
| ωkaI | 0.34 | (0.17, 0.69) | 0.40 | (0.18, 0.71) | |
| σV1I | 0.067 | (0.016, 0.13) | N/A | ||
| σV2I | 0.316 | (0.24, 0.40) | N/A | ||
| σV maxI | 0.08 | (0.04, 0.13) | N/A | ||
| σkaI | 0.92 | (0.86, 0.98) | N/A | ||
| σCL12I | 0.32 | (0.24, 0.40) | N/A | ||
| σI0 | 0.20 | (0.06, 0.30) | N/A | ||
| MDZ : | |||||
| V1S | 78.8 | (48.1, 120.7) | 70.05 | (51.1, 112.1) | |
| V2S | 53.3 | (31.2, 89.7) | 49.08 | (29.9, 81.5) | |
| V maxS | 5125.4 | (3035.2, 7936.4) | 4488 | (3051.8, 7001.3) | |
| CL12S | 42.1 | (23.0, 68.2) | 44.5 | (24.5, 73.4) | |
| ωS | 0.31 | (0.20, 0.51) | 0.34 | (0.21, 0.53) | |
| σV1S | 0.11 | (0.03, 0.22) | N/A | ||
| σV2S | 0.20 | (0.05, 0.40) | N/A | ||
| σV maxS | 0.15 | (0.07, 0.23) | N/A | ||
| σCL12S | 0.20 | (0.05, 0.39) | N/A | ||
| σS0 | 0.10 | (0.03, 0.17) | N/A | ||
Model 2* : a Bayesian three-level hierarchical model for the sample mean and variance.
Model 1** : a Bayesian three-level hierarchical model for the sample mean.
90% CI*** : a 90% credit interval. It is represented by its relative scale to the mean.