Table 3. Population-Average and Subject-Specific AUCR Prediction.

Ki	Dose/Combination (KETO/MDZ)mg	Population-Average AUCR	Subject-Specific AUCR	Between-Subject/Study CV
0.0037	200/2	3.02 ×/÷ 1.112	2.94 ×/÷ 1.258	0.242×/÷ 1.090
0.01	200/2	2.43 ×/÷ 1.084	2.35 ×/÷ 1.222	0.217×/÷ 1.116
0.18	200/2	1.21 ×/÷ 1.014	1.19 ×/÷ 1.085	0.084×/÷ 1.078
0.0037	400/5	3.72 ×/÷ 1.130	3.50 ×/÷ 1.273	0.254×/÷ 1.116
0.01	400/5	3.17 ×/÷ 1.108	2.94 ×/÷ 1.255	0.234×/÷ 1.091
0.18	400/5	1.45 ×/÷ 1.020	1.39 ×/÷ 1.124	0.120×/÷ 1.066
0.0037	800/10	3.93 ×/÷ 1.139	3.61 ×/÷ 1.280	0.249×/÷ 1.155
0.01	800/10	3.56 ×/÷ 1.119	3.34 ×/÷ 1.260	0.224×/÷ 1.139
0.18	800/10	1.78 ×/÷ 1.028	1.69 ×/÷ 1.153	0.151×/÷ 1.058

Note: the results are presented as mean×/÷ (1+CV)*100%.