Table 4.
Kinetic parameter estimates of the best-fit model (model D).
| Parameter | Notes | Final Value | Clearance, L/hr | Half-life, hr |
|---|---|---|---|---|
| k01 | TCE (GI) → TCE (blood) | 104 | - | - |
| k1e | TCE (blood) elimination | 0.393 | 0.0742 | 1.77 |
| k12 | TCE (blood) → TCE (peripheral) | 0.384 | - | - |
| k21 | TCE (peripheral) → TCE (blood) | 0.33 | - | - |
| V1 | Volume of distribution for TCE | 0.189 | - | - |
| k1fT | TCE → TCA formation | 0.0303 | - | - |
| kTe | TCA elimination | 0.0578 | 0.00381 | 12.0 |
| VmT | Volume of distribution for TCA | 0.0660 | - | - |
| k1fD | TCE → DCA formation | 1.46×10−7 | - | - |
| kD12 | DCA: central → peripheral | 10.9 | - | - |
| kD21 | DCA: peripheral → central | 0.500 | - | - |
| kDe | DCA elimination | 1.16 | 8.07×10−5 | 0.598 |
| VmD | Volume of distribution for DCA | 6.96×10−5 | - | - |
| k1fG | TCE → DCVG formation | 4.16×10−6 | - | - |
| kGfC | DCVG → DCVC formation | 0.490 | 0.0168 | 1.41 |
| VmG | Volume of distribution for DCVG | 0.0342 | - | - |
| kCe | DCVC elimination | 0.600 | 0.176 | 1.16 |
| VmC | Volume of distribution for DCVC | 0.293 | - | - |
Clearance is the product between elimination constant and volume of distribution of TCE or each metabolite, reflecting systemic clearance. Units of the reaction constants and volume of distributions are hr−1 and liter, respectively.