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MIC and ED50 values for dihydrophthalazine antifolates and Tmp in a mouse model of septicemia
| Compound |
S. aureus ATCC 29213 (Tmps)
|
S. aureus BAS003908 (Tmpr)
|
||
|---|---|---|---|---|
| MIC (μg/ml) | ED50 range (mg/kg) | MIC (μg/ml) | ED50 range (mg/kg) | |
| Tmp | <0.25 | >3.1 | >128 | 6.25-12.5 |
| BAL0030543 | <0.25 | 1.6-3.1 | 0.5 | 3.1-6.25 |
| BAL0030544 | 1 | 1.6-3.1 | 1 | 3.1-6.25 |
| BAL0030545 | 0.5 | 1.6-3.1 | 1 | 1.6-3.1 |
