FIG. 4.

Anti-WHV efficacy of MIV-210 given orally to woodchucks with chronic WHV infection at 10 mg/kg/day for 4 weeks and then at doses of 10 mg/kg p.o. every third day (n = 3) or 5.0 mg/kg p.o. per day (n = 3) for a further 6 weeks. Animals treated daily with placebo p.o. (n = 3) for 10 weeks were included as controls. Changes in WHV viremia in individual animals (upper panels) and mean changes in WHV viremia (lower panels) during the 4-week induction period for animals treated with MIV-210 (n = 6) and during the subsequent 6-week antiviral maintenance treatments, and for placebo-treated animals, were determined by dot blot hybridization and, when that test was nonreactive, by PCR-NAH. The results are expressed in log₁₀ virus genome equivalents per milliliter.