TABLE 1.
Average pharmacokinetic parameters for FLG after oral administration of MIV-210 to healthy and chronically WHV infected woodchucks
| Pharmacokinetic parameter for FLG | Value (mean ± SD) for:
|
||
|---|---|---|---|
| Healthy woodchucks (n = 4) receiving MIV-210 at:
|
WHV-infected woodchucks (n = 14) receiving MIV-210 at 60 mg/kg | ||
| 10 mg/kg | 40 mg/kg | ||
| Cmax (μM) | 0.54 ± 0.14 | 2.10 ± 1.5 | 3.50 ± 1.9 |
| Tmax (h) | 4.10 ± 1.0 | 3.30 ± 1.5 | 2.90 ± 1.1 |
| AUC0-∞ (μM · h/liter) | 5.15 ± 1.0 | 10.50 ± 4.2 | 20.1 ± 11.3 |
| t1/2 (h) | 5.44 ± 1.2 | 4.20 ± 1.6 | 4.7 ± 0.8 |