TABLE 2.

Mean serum WHV DNA levels prior to, during, and following the 10-week MIV-210 antiviral efficacy study

Time	Placebo			MIV-210 treatment at:
				20 mg/kg/day			60 mg/kg/day
	No. of samples	Mean log10 WHV DNA load (vge/ml)	Range of WHV DNA load (vge/ml)	No. of samples	Mean log10 WHV DNA load (vge/ml)	Range of WHV DNA load (vge/ml)	No. of samples	Mean log10 WHV DNA load (vge/ml)	Range of WHV DNA load (vge/ml)
Pretreatment	6	10.61	1.6 × 1010-6.2 × 1010	6	10.20	6.2 × 108b-9.9 × 1010	6	11.06	3.0 × 1010-2.8 × 1011
During treatment
Wk 2	6	9.15	5.5 × 103a-4.5 × 1010	6	5.45	<102-8.5 × 109	6	5.34	<102-1.2 × 109
Wk 4	6	9.33	7.6 × 103a-12.0 × 1010	6	4.09	<102-5.2 × 109	6	4.32	<102-7.6 × 105
Wk 6	6	9.14	5.6 × 103a-9.1 × 1010	6	4.80	<102-1.1 × 1010	6	4.09	<102-4.8 × 105
Wk 8	5	9.94	1.0 × 108-5.6 × 1010	6	2.91	<102-1.4 × 104	6	3.80	<102-6.1 × 105
Wk 10	5	10.29	8.0 × 109-4.7 × 1010	5	2.97	<102-5.0 × 104	6	3.38	<102-6.2 × 105
After cessation of treatment
Wk 2	4	11.0	5.0 × 1010-2.3 × 1011	5	7.15	<102-7.6 × 1010	6	7.81	<102-2.8 × 1011
Wk 4	4	10.98	5.0 × 1010-2.3 × 1011	5	7.39	<102-1.6 × 1011	6	9.81	<102-4.5 × 1011
Wk 6	4	10.93	3.5 × 1010-1.2 × 1011	5	7.39	<102-1.6 × 1011	6	9.50	<102-9.5 × 1011
Wk 8	4	10.89	4.4 × 1010-1.7 × 1011	5	9.16	<102-2.0 × 1011	6	9.25	<102-1.3 × 1012
Wk 10	4	10.82	3.5 × 1010-1.2 × 1011	5	9.18	<102-2.8 × 1011	6	9.31	<102-1.1 × 1012

^aValue from WM 2637, in which the serum WHV DNA level declined between weeks 2 and 6 and rebounded to a high level at week 8.

^bValue indicates the level of WHV viremia at the time of acquisition of the first liver biopsy specimen for WM 3231, which cleared WHs antigenemia.