TABLE 3.
Mean WHV DNA loads in liver samples collected prior to and after the 10-week treatment with MIV-210 and after the 10-week observation period following the cessation of treatment
| Time of liver biopsy | Placebo
|
Treatment with MIV-210 at:
|
|||||||
|---|---|---|---|---|---|---|---|---|---|
| 20 mg/kg/day
|
60 mg/kg/day
|
||||||||
| No. of biopsy specimens | Mean log10 WHV DNA load (vge/μg) | Range of WHV DNA load (vge/μg) | No. of biopsy specimens | Mean log10 WHV DNA load (vge/μg) | Range of WHV DNA load (vge/μg) | No. of biopsy specimens | Mean log10 WHV DNA load (vge/μg) | Range of WHV DNA load (vge/μg) | |
| Pretreatment | 6 | 7.67 | 2.9 × 107-7.5 × 107 | 6 | 6.27 | 1.2 × 103a-1.3 × 108 | 6 | 7.69 | 2.6 × 107b-6.9 × 107 |
| After 10-wk treatment | 6 | 7.78 | 3.0 × 107-1.2 × 108 | 6 | 3.89 | 4.6 × 102a-1.8 × 107 | 6 | 4.30 | 2.6 × 103b-1.5 × 107 |
| After 10-wk follow-up | 4 | 7.71 | 3.2 × 107-1.0 × 108 | 5 | 6.66 | 2.3 × 102a-9.6 × 107 | 6 | 7.04 | 2.8 × 103b-1.2 × 108 |
a
Value from WM 3231, which cleared WHs antigenemia.
b
Value from WF 2433A, in which WHV viremia diminished rapidly to <102 vge/ml after 2 weeks of treatment with MIV-210 at 60 mg/kg/day p.o. and the suppression was maintained at a comparably low level of viremia beyond the 10-week treatment period.