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Comparative antibacterial effects of aerosol MP-376 and i.p. levofloxacin against P. aeruginosa NH57388A in a model of chronic infection in mice. The treatment groups (n = 8) received drug BID for 72 h by the aerosol or i.p. route. The values shown are the mean log CFU per lung ± standard deviation. Aerosol MP-376 had a greater antimicrobial effect than the same levofloxacin dose administered i.p. (P < 0.05 for comparison of the aerosolized dose versus the same dose administered i.p.).
