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Bactericidal activities of aerosol MP-376, tobramycin, and aztreonam in a model of acute lethal lung infection due to P. aeruginosa ATCC 27853 in mice. The treatment groups (n = 8) received drug twice a day for 48 h by the aerosol route. The values shown are the mean log CFU per lung ± standard deviation. The bacterial counts following the once-daily or BID administration of MP-376 were lower than those following aztreonam treatment (P < 0.05).
