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Effects of aerosol MP-376, tobramycin, and ATM on survival in a model of lethal lung infection due to P. aeruginosa ATCC 27853. Five groups of infected mice (n = 10) were treated with MP-376, tobramycin, and aztreonam by the use of an aerosol microspray device for 48 h. Survival was monitored through day 9 following infection. Both regimens of MP-376 resulted in 100% survival and were superior to aztreonam and tobramycin.
