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Dose-normalized lung homogenate PK parameters of levofloxacin administered i.p. or by the aerosol route as MP-376 in mice
| Antimicrobial | Route of administration | Dose (mg/kg) | Cmaxa (mg/kg) | AUCa (mg · h/kg) |
|---|---|---|---|---|
| MP-376 | Aerosol | 60 | 550 | 106 |
| Levofloxacin | i.p. | 20 | 6.2 (18.6) | 4.1 (12.3) |
The values in parentheses were normalized to 60 mg/kg.
