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Indolmycin, tryptophan, and chuangxinmycin. As structural analogs of tryptophan, indolmycin and chuangxinmycin competitively inhibit bacterial tryptophanyl-tRNA synthetases (3, 38). Chuangxinmycin was provided as a gift from GlaxoSmithKline. The indolmycin used in these studies was chemically synthesized (see Materials and Methods).
