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. 2009 Jun 22;53(9):3972–3980. doi: 10.1128/AAC.00723-09

FIG. 2.

FIG. 2.

(A) Alignment of trpRS1 with other indolmycin resistance genes. The aligned sequences show the region surrounding the HIGH signature consensus of class I aminoacyl-tRNA synthetases. Positions found to correlate to indolmycin resistance in this study are shaded yellow, and the class I aminoacyl-tRNA synthetase signature sequence HIGH is shaded blue. trpRS1 is highly similar in sequence to the indolmycin-resistant tryptophanyl-tRNA synthetase gene SAV4725 from S. avermitilis but is dissimilar to the indolmycin-resistant tryptophanyl-tRNA synthetase gene SGR3809 from S. griseus NBRC 13350 (SGR3809). NCBI accession numbers are provided in the supplementary information (see Table S1 in the supplemental material). (B) Translated sequences of the trpRS1 and SGR3809 genes aligned with homologs from various bacterial species. NCBI accession numbers are provided in the supplementary information (see Table S1 in the supplemental material).